Metronidazole: A culprit to balance and speech

In a country like India, oral metronidazole is the commonly prescribed drug of choice for entities such as amebiasis and visceral abscesses. Oral such cases, it is usually well tolerated and safe but can cause serious neurological adverse events. Peripheral neuropathy commonly encounters in practice but central nervous system toxicity is also well documented as it crosses the blood–brain barrier easily. Neurological toxicity of metronidazole may be due to prolonged administration, high doses, or high cumulative doses. Magnetic resonance imaging (MRI) of brain is the modality of choice to evaluate brain involvement. In the brain, the splenium of the corpus callosum, dentate nucleus of the cerebellum, and posterior pons involvement are commonly seen and diagnostic. Here, we have an interesting case report of a patient who was on oral metronidazole treatment for his large liver abscess, presenting with a complaint of neurological symptoms of unsteady gait, vertigo, dysdiadochokinesia, and difficulty in speech. Moreover, thus suspected as metronidazole drug toxicity and further investigated for the same, and MRI typically shows cerebellar and posterior corpus callosal involvement

Could mid-upper arm circumference be a valid proxy to the body mass index for elderly persons?

Introduction: In elderly persons, due to physiological, anatomical, and functional changes, body mass index (BMI) may not be suitable for the assessment of nutritional status. Mid-upper arm circumference (MUAC) can be a proxy indicator to identify underweight and overweight/obesity among elderly persons. This study aimed to estimate the correlation between MUAC and BMI, and the cutoffs for MUAC using receiver operating characteristic (ROC) analysis. Material and Methods: This survey was carried out in a resettlement colony of Delhi. The participants were residents of the area who were aged 60 years or older, and selected by a simple random sampling technique. The arm span, weight, and MUAC of the participants were measured. The correlation between MUAC and BMI for gender and age group was calculated. The ROC curve was also constructed. Results: A total of 946 eligible participants were enrolled. The correlation between MUAC and BMI was 0.67 (P < 0.001) and 0.76 (P < 0.001) among men and women, respectively. The MUAC cutoff for underweight was <25 cm with a sensitivity of 68.8% and specificity of 84.9%. The area under the curve (AUC) was 0.84 (0.80–0.88). The MUAC cutoff for overweight/obesity was ?27 cm with a sensitivity of 83.9% and specificity of 64.9%, and AUC was 0.78 (0.75–0.82). Conclusion: The MUAC of the participants increased as the BMI of the participants increased. MUAC cutoff was determined using the ROC curve for underweight and overweight/obesity among elderly persons.

Excess Screen Time and its Associated Factors among Young Men in a Rural Community of North India

Screen-based media usage among young people is blooming rapidly due to technological and digital revolution. We conducted community-based cross-sectional study to determine the prevalence of excess screen time and its association with sociodemographic and behavioral patterns in a rural block of Haryana, India. Asemi-structured interview schedule was administered by trained physicians to ascertain screen time in a typical day and various socioeconomic and behavioral factors among a random sample of 860 young men aged 18–24 years. The prevalence of excess screen time was 61.8% (95% confidence interval [CI] 58.4–65.1). It was significantly associated with education (adjusted odds ratio [AOR] 1.7, 95% CI 1.1–2.6) and occupation (AOR 2.2, 95% CI 1.2–3.9) of the father and their sleep duration of ?8 h (AOR 1.6, 95% CI 1.2–2.3). Limiting the screen time as per international standards and behavioral interventions are needed for this young population.

Study of Dimensions of Head and Neck of Human Femur and its Clinical Significance

Introduction: The Study of dimensions of head and neck of femur is important for making of appropriate prosthesis in hip replacement surgery. Different size of dimensions of head and neck of femur can affect the hip joint movement. The dimensions of head and neck of femur is varies according to age, race, heredity, ethnicity and geographical factor. Length of femur and stature of an individual can be determined even if only a fragment of proximal end of femur is available. Objective: To determine the functional implication of variation in dimension of head and neck of femur, which may be helpful for orthopaedic surgeons and forensic experts. Materials and Methods: Fifty human femur bones (25 of each side) were used for the study. Measurement of dimensions of head and neck of femur was done to know the average length of femur, vertical and transverse diameter of head, head circumference, anterior and posterior neck length and neck shaft angle of femur. All the measurement were taken with the help of Osteometric board, Circumference measuring tape, Digital vernier calliper and Goniometer. Results: The following mean values of dimensions of total 50 bones: Length of femur were 435.1±26.0 mm.Vertical and Transverse diameter of head of femur were 40.97±3.46 mm and 41.74 ± 2.76 mm respectively. Head circumference were 133.25±11.57 mm. Anterior and Posterior Neck length were 29.75±5.30 mm and 35.03±4.87 mm respectively. Neck shaft angle were 125.96±6.10 degree . Conclusion: Appropriate prosthesis for orthopaedic surgeries can be designed from the result of this study.

Gas Under Right Hemidiaphragm: A Rare Presentation of Unruptured Liver Abscess

A perforated liver abscess mimics hollow viscus perforations. It may be accompanied by pneumoperitoneum and peritonitis. A hollow viscus perforation appears to be the most common cause of gas under diaphragm. In about 10% of the cases, it can be due to rare abdominal and extra-abdominal causes. One of the causes could be intra-abdominal infection caused by gas-forming organisms. We are reporting a rare case of pneumoperitoneum resulting from an unruptured liver abscess in an old male with no comorbidity. An unruptured pyogenic right lobe liver abscess in a 70-year-old male was accompanied by X-ray flat plate abdomen features suggestive of free gas under the right hemidiaphragm. Culture of the pus drained from liver abscess grew Klebsiella sensitive to piperacillin and tazobactam, and antibiotic treatment was administered.

The effectiveness of the two-layered closure of persistent Oroantral Fistula using Buccal Fat Pad and Buccal Advancement Flap.

Background: A prospective clinical study was conducted to assess the effectiveness of the two -layered closure of recurrent Oroantral Fistula using Buccal Fat Pad and Buccal Advancement Flap. Materials and methods: Twenty patients with persistent OAFs larger than 5 mm were treated with two layered closure using Buccal Fat Pad and Buccal Advancement Flap. They were followed clinically and radiographically for 5 years after surgery to monitor the durability and effectiveness of the two layered closure of the OAF. Result: The procedure was successful in all patients. The healing process was satisfactory,with no breakdown or liquefaction necrosis postoperatively. No complications were observed during the follow-up period. Conclusion: The results of this study support the view that the use of the double-layered closure using BFP with buccal advancement flap is a durable, convenient, and effective method for the treatment of a persistent large OAF.

What a Clinical Hematologist should Know about B Cells?

B cells are very crucial part of our immune system. They protect us from various infections by secreting antigen-specific antibodies, which neutralize the infectious agents. It is important for a clinical hematologist to know about the B cell development, function and the diseases developing from the quantitative or qualitative defects in B cells. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of B cells.

Sustainable control of malaria employing Gambusia fishes as biological control in Jalore and Barmer districts of Western Rajasthan

Sardar Sarovar Irrigation Canal system was constructed by Narmada Valley Development Authority (NVDA) to cater to drinking water as well as for irrigation purposes in Jalore and Barmer districts of Western Rajasthan. To cater to the needs of water for the villagers in the command areas, ‘Diggies’ (surface water tanks) with ‘Sumpwells’ (water supply surface tanks) were installed. In a health impact assessment study of the irrigation canals from December 2010 to February 2016, the breeding of two major malaria vectors. An. culicifacies and An. stephensi were observed in diggies and sumpwells. As a biological control, Gambusia affanis fishes were employed for larval control in such stagnated water sites during the intervention phase viz. February 2012 in 251 diggies and 251 sumpwells. A significant reduction of breeding in diggies (99.54%) and sumpwells (97.81%) was observed. The positivity and larval density (dip index) were monitored in the control from up to February 2016 for their sustainability.

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stability renders PF74 a poor antiviral lead. We report herein our medicinal chemistry efforts toward identifying novel and metabolically stable small molecules targeting the PF74 binding site. Specifically, we replaced the inter-domain-interacting, electron-rich indole ring of PF74 with less electron-rich isosteres, including imidazolidine-2,4-dione, pyrimidine-2,4-dione, and benzamide, and identified four potent antiviral compounds (

Management of patients with allergy to local anesthetics: two case reports

Lidocaine is the most commonly used local anesthetic (LA) agent in various dental as well as oral and maxillofacial procedures. Although rare, adverse effects and allergic reactions to lidocaine have been reported. In patients with suspected allergy to LA or a history of such reaction, careful history-taking and allergy testing should be performed to choose an alternative LA agent to avoid any adverse effects. Here, we present two cases of delayed hypersensitivity reaction to lidocaine, wherein the patients presented with erythema, edema, and itching. Intradermal testing confirmed allergic reaction to lidocaine, and the patients underwent successful dental treatment using an alternative LA agent. This report highlights the importance of allergy testing prior to LA use considering the serious consequences of allergy to these agents and describes the management of such patients using an alternative LA agent.

Biomarker testing for advanced lung cancer by next-generation sequencing; a valid method to achieve a comprehensive glimpse at mutational landscape

Background: Next-generation sequencing (NGS) based assay for finding an actionable driver in non-small-cell lung cancer is a less used modality in clinical practice. With a long list of actionable targets, limited tissue, arduous single-gene assays, the alternative of NGS for broad testing in one experiment looks attractive. We report here our experience with NGS for biomarker testing in hundred advanced lung cancer patients. Methods: Predictive biomarker testing was performed using the Ion AmpliSeq™ Cancer Hotspot Panel V2 (30 tumors) and Oncomine™ Solid Tumor DNA and Oncomine™ Solid Tumor Fusion Transcript kit (70 tumors) on IonTorrent sequencing platform. Results: One-seventeen distinct aberrations were detected across 29 genes in eighty-six tumors. The most commonly mutated genes were TP53 (43% cases), EGFR (23% cases) and KRAS (17% cases). Thirty-four patients presented an actionable genetic variant for which targeted therapy is presently available, and fifty-two cases harbored non-actionable variants with the possibility of recruitment in clinical trials. NGS results were validated by individual tests for detecting EGFR mutation, ALK1 rearrangement, ROS1 fusion, and c-MET amplification. Compared to single test, NGS exhibited good agreement for detecting EGFR mutations and ALK1 fusion (sensitivity- 88.89%, specificity- 100%, Kappa-score 0.92 and sensitivity- 80%, specificity- 100%, Kappa-score 0.88; respectively). Further, the response of patients harboring tyrosine kinase inhibitor (TKI) sensitizing EGFR mutations was assessed. The progression-free-survival of EGFR positive patients on TKI therapy, harboring a concomitant mutation in PIK3CAmTOR and/or RAS-RAF-MAPK pathway gene and/or TP53 gene was inferior to those with sole-sensitizing EGFR mutation (2 months vs. 9.5 months, P = 0.015). Conclusions: This is the first study from South Asia looking into the analytical validity of NGS and describing the mutational landscape of lung cancer patients to study the impact of co-mutations on cancer biology and treatment outcome. Our study demonstrates the clinical utility of NGS testing for identifying actionable variants and making treatment decisions in advanced lung cancer

The efficacy of an ayurvedic preparation of yashtimadhu (Glycyrrhiza glabra) on radiation-induced mucositis in head-and-neck cancer patients: A pilot study

Background: Oral mucositis is a common and debilitating painful side effect of many forms of chemotherapy and radiation therapy. Mucositis may lead to dose reductions and unplanned interruptions of chemotherapy and/or radiotherapy (RT) and often affects patients' quality of life. Aim: The objective of the study was to assess the efficacy of the ayurvedic preparation in decreasing the severity of mucositis in head-and-neck cancer patients receiving concomitant chemoradiotherapy. Materials and Methods: In this prospective randomized study, the patients were divided into three groups. Group 1 patients received conventional mucositis treatment, whereas Group 2 patients received ayurvedic preparation Yashtimadhu in addition to conventional treatment. Group 3 patients received honey for local application in oral cavity as well as one tea spoon of honey twice daily orally in addition to routine conventional treatment. All the patients were assessed for mucositis at the end of every week during the RT for a period of 6 weeks. Results: A significant difference was observed between the groups at each time point. Nearly 42.85% of patients in conventional treatment arm developed Grade 3 mucositis, 20% of patients developed Grade 3 mucositis in group where honey was given, and only 15.5% of patients developed Grade 3 mucositis in Yastimadhu group. Unplanned treatment breaks and hospitalization of patients were reduced with the use of yashtimadhu as compared to other two groups. Conclusion: Yashtimadhu was observed to be effective and delayed the development of severe form of mucositis. The drug appeared to be more efficient in the management of radiation-induced mucositis

Hearing Loss in Thalassemic Children on Chelation Therapy

Background: Thalassemia is a common genetic hematological disorder worldwide. It is also common in North India includingJammu region. These patients need lifelong repeated blood transfusions and iron chelation therapy for their survival. Chelationtherapy is known to be associated with various complications including sensorineural hearing loss (SNHL). Till now, no dataare available regarding SNHL in pediatric thalassemia major patients in Jammu region. Hence, we planned a study to assessthe prevalence of hearing loss in children with thalassemia major in the age group of 10–20 years.Methods: All the children with beta-thalassemia major in the age group of 10–20 years registered with Thalassemia Day CareCenter, Department of Pediatrics, SMGS Hospital, Government Medical College, Jammu, were enrolled in this cross-sectionalstudy. Hearing was assessed by pure tone audiometry. Clinical and demographic data of these patients were recorded onpretested pro forma and analyzed.Results: A total number of 34 children with thalassemia in the age group of 10–20 years were enrolled in this study whichcomprised 18 males and 16 females. Out of these 34 patients, 5 (14.7%) were found to have SNHL and 1 (2.9%) had conductivehearing loss. Four of the five patients in SNHL group had low- as well as high-frequency mild hearing loss (25–40 db) whileone patient had high-frequency mild hearing loss at 4000 HZ. Four out of these five patients had unilateral hearing loss on theleft side while one had bilateral SNHL. Two out of five patients in the SNHL group were taking chelation therapy in the form ofcombination of deferiprone and deferasirox at the dose of 75–100 mg/kg/day and 30–40 mg/kg/day, respectively, for more than5 years. The other three patients were taking only deferasirox at the dose of 30–40 mg/kg/day for more than 5 years.Conclusions: Regular blood transfusions and chelation therapy are essential for long-term survival of thalassemia majorpatients but are also associated with complications like SNHL.

Genetic diversity analysis of specialty glutinous and low-amylose rice (Oryza sativa L.) landraces of Assam based on Wx locus and microsatellite diversity

The sticky rice of Assam is traditionally classified as bora (glutinous) and chokuwa (semi-glutinous) basedon their stickiness after cooking. The Waxy (Wx) gene encodes for granule-bound starch synthase (GBSS)that controls the synthesis of amylose, which is a key determinant of rice end-use quality attributes. In thisreport, we analysed the level of variation in grain quality traits in a collection of bora and chokuwacultivars, and examined the nucleotide diversity at the Wx locus of selected rice accessions to identify thepossible cause of low-amylose in these rice cultivar groups. The Wx gene sequencing from 24 bora andchokuwa cultivars revealed several nucleotide variations that can explain the variation in the amylosephenotypes. The nucleotide polymorphisms in the downstream intron regions were similar to those reportedin Bangladeshi Beruin cultivars. Among the Wx polymorphisms, the CTn microsatellite in exon 1 and G/TSNP in intron 1 (G/T-Int1) should be considered for marker assisted breeding involving bora cultivars. TheWx gene tree, classified the bora accessions possessing the G/T-Int1 SNP as japonicas. However, clusteranalysis using microsatellite markers classified the bora and chokuwa cultivars as indica, and intermediateof indica-aus. The findings of this study supplemented our understanding on the evolution of the Wx geneunder human selection. The results will assist plant breeders to effectively improve the bora and chokuwalandraces.

Computed Tomography Guided Fine Needle Aspiration Cytology of Clinically Suspected Lung Neoplasm: An Institutional Experience in Kumaun Region of Uttarakhand

Intrduction: Lung carcinoma is the most common causeof cancer related mortality worldwide. Lung carcinoma ismalignant lung neoplasm characterized by uncontrolledcell proliferation in lung tissue. Primary lung cancers arederived from epithelial cells. This present study was designedand conducted with an aim to evaluate demographics,imaging characteristics, staging of lung cancer by MDCT,cytopathological spectrum of lung cancers in Kumaun regionof Uttarakhand and to assess the diagnostic accuracy of CTguided FNAC in evaluation of suspected lung masses.Material and methods: This institution based prospectivecross-sectional study was conducted at Government medicalCollege and Swami Ram Cancer Hospital, Haldwani from2018 to 2020 for two years. Computed tomography guidedFNAC was done in 102 patients. After proper history andthrough clinical examination, patients were subjected to CTguided aspiration using aseptic precautions. Air-dried smearswere stained with May–Grunwald–Giemsa stain (MGG).Alcohol fixed smears were stained using routine Papanicolaou(Pap) and Hematoxyline & Eosine (H & E) method.Results: The study consisted of 102 patients in age groupof 33-86 years. There were 81 males (79.41%) and 21females (20.58%) and adequate sample was obtained in 94patients giving adequacy rate of 92.15%. The most commoncytological presentation was squamous cell carcinoma in 49patients (52.12%) followed by adenocarcinoma in 23 patients(24.46%). Pneumothorax was seen in 8 patients (7.84%) ofpatients and no patient required chest tube insertion. In ourstudy computed tomography (CT) guided FNAC was foundsuccessful in making the diagnosis in 91 cases (89.21%).Conclusion: Computed tomography (CT) guided FNAC is areliable, safe, less expensive, less time consuming, minimallyinvasive procedure with a high diagnostic accuracy forevaluation of suspected lung neoplasm.

Morphometric Study In The Variations Of Number, Position And Direction Of Nutrient Foramen In The Clavicle

Background: Clavicle is a curved modified long bone placed horizontally at the root of neck. It transmits theweight of upper limb to the axial skeleton. The aim of this study is to determine position, number, and directionof nutrient foramen.Material method: The present study was conducted on 50 (25 right and 25 left) dried clavicles, in the departmentof Anatomy, Forensic medicine, Narayan Medical College, Jamuhar, Sasaram, Bihar.Result: The nutrient foramen was present in all the clavicles. One nutrient foramen was present in 70%, two in24% and three in 6% of clavicles. Predominant position of nutrient foramen was on the posterior surface(55.88%) and predominant location was in the middle one third (70.58%) of clavicles. Direction of all the nutrientforamina were towards the acromial end.Conclusion: The study of number, position, location and direction of nutrient foramina of clavicles are useful topreserve the arterial supply during surgical procedure like internal fixation and vascularised bone graft.KEY WORDS: Clavicle, nutrient foramen, foramen index, acromial end, sternal end, vascularised bone graft

Comparative Study Of Tendon And Nerve Gliding Exercises Versus Kinesiotaping For Carpel Tunnel Syndrome

Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, with a reported annual incidence per 100,000 persons ranging from 324 to 524 among women and 135 to 303 among men There are several treatment options which they can be broadly categorised into surgical and non-surgical. The various nonsurgical methods include: use of hand brace, splinting of the wrist, ultrasonic therapy, laser therapy, oral steroids, non-steroid anti-inflammatory drugs (NSAIDs), oral vitamin B6, local injection of corticosteroids, transcutaneous electrical nerve stimulation. There are a limited number of studies on the effectiveness of kinesiotaping in CTS. The purpose of this study was to evaluate the therapeutic efficacy of ultrasound treatment combined with nerve and tendon gliding exercises and kinesiotaping and to compare the two regimens. Materials and methods: In the present study a convenience sample of 20 individuals between 25 to 55 years suffering from mild to moderate carpel tunnel syndrome were randomly and evenly divided into 2 groups : Group A ( Tendon and Nerve gliding exercises ) & Group B ( Kinesio taping). Group A received Ultrasound over the area of carpel tunnel along with tendon and nerve gliding exercises 5 times a week for 2 weeks. Group B received Ultrasound 5 times a week over the carpel tunnel area along with kinesiotaping with 5 day interval for 2 weeks. At the end of 2 weeks the outcome measures which included VAS, Boston CTS Questionnaire assessed in both the groups and the data was statistically analysed. Results: Intragroup analysis of both groups pre and post intervention showed statistically significant values for both the outcome measures VAS and BCTS Questionnaire ( p value< 0.05). Intergroup analysis also showed statistically significant values for outcome measures inferring that Group B was better than Group A (p value< 0.05). Conclusion: The study concluded that both kinesiotaping along with Ultrasound as well as tendon and nerve gliding exercises with ultrasound are effective in reducing pain and improving functional activities in patients with Carpel Tunnel Syndrome. Kinesiotaping with Ultrasound is more effective than tendon and nerve gliding exercise

Morphometric Study Of Segments Of Humerus In Population Of Bihar

Background: The humerus has upper end, lower end and a cylindrical shaft. In absence of cranium, pelvis andlong bones of lower limbs, estimation of living stature can be assessed by long bones such as humerus, radiusand ulna. We can also find out the total length of humerus by its fragments. Morphometry of distal end ofhumerus is also important for determination of sex.Materials and methods: The present study was conducted on 60 dry humerus of unknown age and sex collectedfrom department of anatomy of Narayan Medical College and also from other medical colleges of Bihar. 6different parameters were taken from this study.Result: Total 60 humerus were included in this study, out of which 30 were right and 30 were left. Mean maximumlength of humerus were 307.58±8.46 mm. Mean transverse and vertical diameter of head of humerus were39.06±1.26 mm and 41.43±1.02 mm respectively. Mean distance between proximal & distal edge of olecranonfossa were 18.39±0.93 mm. Mean distance between distal edge of olecranon fossa & trochlea 15.00±0.82 mm.Mean distance between proximal edge of olecranon fossa & distal edge of trochlea were 33.39±1.32 mm.Conclusion: The knowledge of Morphometric segments of Humerus is important to establish the length of humerus,stature, age and sex of individual and it is important for anatomists, forensic experts, archeologists. It is alsohelpful for orthopaedic surgeons in proximal and distal fracture of humerus and its reconstructive surgery forvarious implants

Prevalence of elderly patients who refuse to get discharge from coronary intensive care unit in a tertiary care hospital of North India: a pilot study

Background: The elderly population ≥60 years is increasing as the life span is increasing. So is the number of elderly patients who are refusing to get discharge from the hospital is also increasing. Authors are conducting this study in the elderly population who want to stay against medical advice.The aim to find the prevalence of elderly patients who refuse to get discharge from Coronary Care Unit (CCU) in a Tertiary care hospital of North IndiaMethods: A retrospective, observational study conducted in patients of age ≥60 years admitted to the coronary intensive care unit of a tertiary health care centre who refused discharge from the unit, were included in the study. Results: Of the 575 patients 44(7.65%) were willing to stay against medical advice. Of these 24(54.5%) were males and 20(45.5%) females. 6(13.6%) patients were terminally ill suffering from malignancies. Among all the patients who were willing to stay against medical advice, 8(18.2%) were covered by some health insurance scheme of either State or Central Government. 3(6.8%) patients were discharged after 24 hours, 22(50%) patients after 48 hours, 14(31.9%) patients after 72 hours and 5(11.3%) patients after 96 hours of advising discharge from hospital.Conclusions: As the intensive care beds at tertiary healthcare level are limited, the treatment of other salvageable sick patients who need the intensive care is affected by the unnecessary stay in hospital. Apart from the worsened nurse to patient ratio this increases the cost of treatment. This is need of hour to provide safe environment for the elderly outside the hospital settings and increase resources to provide better homecare.

Fundus fluorescein angiographic assessment of patients with proliferative diabetic retinopathy and macular edema before and after intravitreal injection of Bevacizumab

Background: To assess the role of intravitreal bevacizumab (1.25 mg) in patients with proliferative diabetic retinopathy with macular edema in terms of change in leakage area and best-corrected visual acuity.Methods: This prospective randomized interventional study was conducted in the Department of Ophthalmology from September 2013 to August 2015 and included thirty eyes of twenty patients.After a detailed history and ocular examination, diagnosed cases of proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) underwent sequential fundus fluorescein angiography. Bevacizumab was administered intravitreally. Patients were assessed two hours after injection for anterior chamber reaction and intraocular pressure and were advised follow-ups at 24 hours and then at 1, 4, 8 and 12 weeks. For the outcome, the change of retinal new vessels by assessment of leakage area using Quantitative Planimetric Analysis (QPA) of photographs as well as the change in best-corrected visual acuity (BCVA) from baseline to the 12 weeks follow-up, were done. Results were analyzed statistically by applying t-test.Results: Intravitreal bevacizumab injection lead to a significant decrease in leakage in DME and PDR, and improvement in mean BCVA. The effect was maximum at 4 weeks which weaned off as the study progressed through it remains statistically significant at the end of 12 weeks.Conclusions: Intravitreal bevacizumab plays a major role in treating and reducing visual deterioration in patients with proliferative diabetic retinopathy and diabetic macular edema.